TTI2

Across TCGA patient cohorts, TTI2 mutation is significantly associated with the RNA expression of many other genes, with 2,008 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTI2-associated genes across cancer lineages are HNRNPMP2, TRAJ57, and RNA5SP467. Each is linked with TTI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTI2-to-partner and partner-to-TTI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HNRNPMP2 grouped by TTI2-low versus TTI2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTI2→partner) and Y-score (partner→TTI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	HNRNPMP2 →	+0.100	+6.342	<.001	.001	3	2
SKCM	TRAJ57 →	+0.760	+5.362	<.001	.005	3	2
CESC	RNA5SP467 →	+0.407	+5.539	<.001	.004	3	2
LUSC	MIR8076 →	+0.658	+4.984	<.001	.009	3	2
CESC	OPCML-IT1 →	+0.196	+5.201	<.001	.007	3	2
CESC	OR4A10P →	+0.115	+7.164	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,008 associations by consensus.

HNRNPMP2 by TTI2 expression — CESC

Explore this box plot interactively →