TTI2

Across TCGA patient cohorts, TTI2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTI2-associated genes across cancer lineages are EGFR_pY1068, ATM, and 4E-BP1. Each is linked with TTI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTI2-to-partner and partner-to-TTI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TTI2-low versus TTI2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTI2→partner) and Y-score (partner→TTI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.349	-4.087	<.001	<.001	3	2
UCEC	ATM →	-0.486	-2.321	.009	.006	3	2
UCEC	4E-BP1 →	+0.301	+2.999	.007	.035	3	2
UCEC	14-3-3_beta →	-0.111	-2.558	.007	.010	3	1
UCEC	EGFR →	-0.273	-2.321	<.001	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.204	-2.115	.003	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

EGFR_pY1068 by TTI2 expression — UCEC

Explore this box plot interactively →