TTI2

Across TCGA cell cohorts, TTI2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,204 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TTI2-associated GO terms across cancer lineages are Positive regulation of DNA damage checkpoint, Regulation of DNA damage checkpoint, and DNA-templated transcription initiation. Each is linked with TTI2 in more than 15 cancer types. Because this analysis shows association rather than direction, both TTI2-to-partner and partner-to-TTI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA damage checkpoint grouped by TTI2-low versus TTI2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TTI2→partner) and Y-score (partner→TTI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of DNA damage checkpoint →	+0.157	+1.382	.004	.004	2	16
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA damage checkpoint →	+0.115	+1.132	<.001	<.001	3	14
BONE	DNA-templated transcription initiation →	+0.077	+0.720	<.001	<.001	3	14
LUNG_NSCLC_LUSC	snRNA processing →	+0.096	+0.994	<.001	.003	3	14
OVARY	Formation of extrachromosomal circular DNA →	+0.093	+0.579	<.001	<.001	3	13
BLOOD_Lymphoma	Negative regulation of sister chromatid cohesion →	+0.092	+0.657	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,204 associations by consensus.

Positive regulation of DNA damage checkpoint by TTI2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →