TTI2

Across TCGA cell cohorts, TTI2 mutation is significantly associated with the mutation status of many other genes, with 3,688 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTI2-associated genes across cancer lineages are VWA8, SLC2A9, and ZNF211. Each is linked with TTI2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TTI2-to-partner and partner-to-TTI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VWA8 grouped by TTI2-low versus TTI2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTI2→partner) and Y-score (partner→TTI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VWA8 →	+3.338	+4.083	.003	.003	1	4
SKIN	SLC2A9 →	+5.824	+5.824	.002	.002	1	3
SKIN	ZNF211 →	+4.824	+5.392	.004	.004	1	3
LARGE_INTESTINE	ATP2C2 →	+2.159	+3.807	.007	.007	1	3
SKIN	SPAG5 →	+4.824	+5.392	.004	.004	1	3
SKIN	LRRC8A →	+4.824	+5.392	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,688 associations by consensus.

VWA8 by TTI2 expression — BLOOD_Leukemia

Explore this box plot interactively →