TTI1

Across TCGA patient cohorts, TTI1 mutation is significantly associated with the RNA expression of many other genes, with 2,389 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTI1-associated genes across cancer lineages are PDE12, LINC02663, and RPS11P1. Each is linked with TTI1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TTI1-to-partner and partner-to-TTI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDE12 grouped by TTI1-low versus TTI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTI1→partner) and Y-score (partner→TTI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDE12 →	+0.282	+1.425	.007	.001	3	4
SKCM	LINC02663 →	+0.481	+2.271	<.001	.004	3	4
CESC	RPS11P1 →	+0.084	+3.516	.005	.001	3	3
PAAD	RPL26P3 →	+0.151	+5.053	<.001	.008	3	3
LIHC	IGHD6-6 →	+0.939	+5.149	<.001	.003	3	3
LUAD	DDX21 →	+0.684	+3.494	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,389 associations by consensus.

PDE12 by TTI1 expression — UCEC

Explore this box plot interactively →