TTI1

Across TCGA pan-cancer cohorts, TTI1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TTI1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TTI1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TTI1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, COAD, and BLCA are the cancer types where TTI1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTI1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.011	<.001	12	view →
COAD	Male	IV	+1.452	<.001	11	view →
BLCA	All	III,IV	+0.849	<.001	11	view →
KIRC	Female	All	+0.509	<.001	11	view →
THCA	All	II,III,IV	−0.586	<.001	10	view →
STAD	Male	II,III,IV	+1.374	<.001	9	view →
LIHC	Female	II,III,IV	+1.115	<.001	9	view →
LUAD	All	III,IV	+0.870	<.001	9	view →
BRCA	All	III,IV	+0.810	<.001	6	view →
CHOL	Male	All	+1.838	<.001	5	view →
LUSC	Male	II,III,IV	+1.020	<.001	5	view →
KIRP	All	II,III,IV	+0.592	.004	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TTI1–HNSC

Open the HNSC breakdown →