TTI1

Across TCGA pan-cancer cohorts, TTI1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated TTI1 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher TTI1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TTI1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

LIHC, UVM, and KIRC are the cancer types where TTI1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Tertile	All	0.417	0.644	<.001	78	view →
UVM	OS	Tertile	All	0.476	0.929	.002	59	view →
KIRC	DFS	Median	All	0.762	0.488	<.001	56	view →
MESO	DFS	Quartile	III,IV	0.240	0.480	.001	53	view →
LGG	DFS	Median	All	0.660	0.818	<.001	53	view →
BLCA	DFS	Median	All	0.562	0.666	.002	52	view →
UCEC	DFS	Median	All	0.793	0.880	.001	34	view →
LUSC	DFS	Tertile	III,IV	0.297	1.000	.001	30	view →
READ	OS	Quartile	II,III,IV	1.000	0.273	.004	30	view →
ACC	DFS	Tertile	All	0.535	0.885	<.001	29	view →
UCS	OS	Tertile	IV	0.922	0.253	.024	24	view →
SARC	DFS	Quartile	All	0.221	0.547	<.001	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

TTI1–LIHC (DFS)

Open the LIHC breakdown →