TTI1

Across TCGA patient cohorts, TTI1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTI1-associated genes across cancer lineages are ATM, p62 Lck ligand, and HER2. Each is linked with TTI1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TTI1-to-partner and partner-to-TTI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TTI1-low versus TTI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTI1→partner) and Y-score (partner→TTI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.326	-1.678	.020	.021	3	4
UCEC	p62 Lck ligand →	+0.213	+1.290	.035	.034	3	2
SKCM	HER2 →	+0.377	+3.169	.014	.019	3	1
SKCM	TAZ →	+0.389	+2.824	<.001	.034	3	1
UCEC	14-3-3_beta →	-0.074	-1.673	.017	.040	3	1
UCEC	Fibronectin →	-0.215	-1.575	.035	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ATM by TTI1 expression — UCEC

Explore this box plot interactively →