TTI1

Across TCGA cell cohorts, TTI1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,961 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TTI1-associated GO terms across cancer lineages are Regulation of double-strand break repair via homologous recombination, Transcription preinitiation complex assembly, and Mitotic cell cycle checkpoint signaling. Each is linked with TTI1 in more than 18 cancer types. Because this analysis shows association rather than direction, both TTI1-to-partner and partner-to-TTI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of double-strand break repair via homologous recombination grouped by TTI1-low versus TTI1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TTI1→partner) and Y-score (partner→TTI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of double-strand break repair via homologous recombination →	+0.136	+1.133	<.001	<.001	3	19
BONE	Transcription preinitiation complex assembly →	+0.075	+1.000	<.001	<.001	3	18
BONE	Mitotic cell cycle checkpoint signaling →	+0.112	+0.900	.001	<.001	3	18
BONE	Protein localization to chromatin →	+0.113	+0.678	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via homologous recombination →	+0.082	+0.888	<.001	<.001	3	18
URINARY_TRACT	Positive regulation of cell cycle checkpoint →	+0.131	+0.613	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,961 associations by consensus.

Regulation of double-strand break repair via homologous recombination by TTI1 expression — BONE

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