TTI1

Across TCGA cell cohorts, TTI1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTI1-associated genes across cancer lineages are BRDT, RSC1A1, and SPATA22. Each is linked with TTI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTI1-to-partner and partner-to-TTI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRDT grouped by TTI1-low versus TTI1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTI1→partner) and Y-score (partner→TTI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BRDT →	+0.133	+3.906	<.001	.002	3	1
LARGE_INTESTINE	RSC1A1 →	+0.814	+3.410	.005	.007	3	1
LUNG_SCLC	SPATA22 →	+1.193	+4.817	<.001	.001	3	1
LUNG_SCLC	TRIML1 →	+0.219	+4.269	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

BRDT by TTI1 expression — LARGE_INTESTINE

Explore this box plot interactively →