TTC9B

Across TCGA cell cohorts, TTC9B mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TTC9B-associated genes across cancer lineages are OR4S2, OR4P4, and LCN1. Each is linked with TTC9B in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC9B-to-partner and partner-to-TTC9B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4S2 grouped by TTC9B-low versus TTC9B-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC9B→partner) and Y-score (partner→TTC9B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR4S2 →	+0.020	+5.285	<.001	.003	3	1
STOMACH	OR4P4 →	+0.016	+5.285	<.001	.003	3	1
BLOOD_Leukemia	LCN1 →	+0.030	+4.922	.002	.009	3	1
BLOOD_Leukemia	PRM3 →	+0.090	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	TMEM239 →	+0.086	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR4S2 by TTC9B expression — STOMACH

Explore this box plot interactively →