TTC9B

Across TCGA pan-cancer cohorts, TTC9B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TTC9B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TTC9B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TTC9B is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

HNSC, KICH, and LIHC are the cancer types where TTC9B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTC9B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.195	<.001	11	view →
KICH	Male	All	−0.415	<.001	10	view →
LIHC	Female	All	+0.183	<.001	7	view →
LUSC	All	All	+0.159	.002	7	view →
LUAD	Female	II,III,IV	+0.303	.002	6	view →
BRCA	Female	All	+0.105	<.001	6	view →
KIRC	All	All	−0.090	<.001	5	view →
COAD	All	II,III,IV	+0.350	.001	4	view →
UCEC	All	All	+0.182	.012	4	view →
THCA	Female	All	+0.149	.011	3	view →
ESCA	All	All	+0.206	.023	2	view →
CHOL	Female	All	+0.123	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TTC9B–HNSC

Open the HNSC breakdown →