TTC9B

Across TCGA pan-cancer cohorts, TTC9B RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TTC9B data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TTC9B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TTC9B expression acts as an unfavorable survival marker, although some lineages such as CESC and SCLC show a favorable association.

UVM, MESO, and KIRC are the cancer types where TTC9B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.319	0.685	<.001	110	view →
MESO	OS	Median	III,IV	0.279	0.499	<.001	95	view →
KIRC	DFS	Tertile	II,III,IV	0.383	0.614	<.001	88	view →
ACC	DFS	Tertile	All	0.261	0.707	.001	66	view →
CESC	OS	Tertile	All	0.784	0.480	<.001	28	view →
SCLC	DFS	Median	II,III,IV	0.636	0.281	<.001	21	view →
COAD	DFS	Median	II,III,IV	0.351	0.700	.010	20	view →
KIRP	OS	Quartile	III,IV	0.109	0.590	.001	19	view →
ESCA	OS	Median	All	0.659	1.000	.020	18	view →
READ	DFS	Quartile	III,IV	0.733	0.241	.025	17	view →
UCS	OS	Tertile	IV	0.239	1.000	.036	12	view →
CHOL	OS	Median	II,III,IV	0.888	0.382	.022	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TTC9B–UVM (DFS)

Open the UVM breakdown →