TTC8

Across TCGA patient cohorts, TTC8 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC8-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and MEK1. Each is linked with TTC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC8-to-partner and partner-to-TTC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by TTC8-low versus TTC8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC8→partner) and Y-score (partner→TTC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.091	-3.295	.013	.009	3	2
UCEC	eIF4E →	+0.174	+2.736	.025	<.001	3	2
UCEC	MEK1 →	+0.391	+2.906	.003	.001	3	2
UCEC	C-Raf →	+0.185	+3.459	<.001	.005	3	2
UCEC	Di-Ras3 →	-0.140	-3.308	.010	.009	3	2
UCEC	EGFR_pY1068 →	-0.223	-1.847	.015	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

14-3-3_beta by TTC8 expression — UCEC

Explore this box plot interactively →