TTC8

Across TCGA pan-cancer cohorts, TTC8 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TTC8 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher TTC8 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TTC8 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCEC show a favorable association.

BRCA, UCEC, and UVM are the cancer types where TTC8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Tertile	All	0.962	0.883	<.001	108	view →
UCEC	OS	Median	All	0.919	0.828	<.001	84	view →
UVM	DFS	Median	III,IV	0.267	0.796	.002	73	view →
KIRC	OS	Tertile	All	0.723	0.540	<.001	35	view →
ACC	OS	Median	III,IV	0.829	0.176	<.001	24	view →
LGG	OS	Quartile	All	0.626	0.865	<.001	24	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	24	view →
LAML	DFS	Median	All	0.528	0.249	.007	22	view →
MESO	OS	Tertile	All	0.791	0.379	.012	18	view →
SKCM	DFS	Quartile	All	0.669	0.517	.017	14	view →
LUSC	DFS	Tertile	III,IV	0.170	0.771	.008	14	view →
THCA	DFS	Tertile	All	0.941	0.684	.009	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TTC8–BRCA (OS)

Open the BRCA breakdown →