TTC8

Across TCGA pan-cancer cohorts, TTC8 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TTC8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TTC8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TTC8 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and KICH are the cancer types where TTC8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTC8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.603	<.001	10	view →
THCA	All	III,IV	−0.696	<.001	9	view →
KICH	Female	II,III,IV	−1.005	<.001	8	view →
KIRP	All	II,III,IV	+0.573	<.001	7	view →
KIRC	All	II,III,IV	−0.387	<.001	7	view →
COAD	All	II,III,IV	+0.468	<.001	6	view →
CHOL	All	II,III,IV	+1.575	.001	5	view →
BLCA	Female	III,IV	+0.750	.009	5	view →
LUAD	Male	All	+0.502	<.001	5	view →
LIHC	Female	All	+0.438	.012	5	view →
BRCA	All	II,III,IV	+0.318	.002	4	view →
ESCA	All	All	+0.816	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TTC8–HNSC

Open the HNSC breakdown →