TTC8

Across TCGA cell cohorts, TTC8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,046 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TTC8-associated GO terms across cancer lineages are Vesicle tethering to Golgi, Vesicle tethering, and Positive regulation of ERAD pathway. Each is linked with TTC8 in more than 13 cancer types. Because this analysis shows association rather than direction, both TTC8-to-partner and partner-to-TTC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vesicle tethering to Golgi grouped by TTC8-low versus TTC8-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC8→partner) and Y-score (partner→TTC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Vesicle tethering to Golgi →	+0.129	+1.190	<.001	<.001	3	14
OESOPHAGUS	Vesicle tethering →	+0.087	+0.969	.007	.004	3	13
SOFT_TISSUE	Positive regulation of ERAD pathway →	+0.103	+0.761	<.001	<.001	3	12
STOMACH	Protein localization to non-motile cilium →	+0.090	+1.079	.001	<.001	3	11
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.159	+1.011	<.001	.004	3	11
LIVER	Protein localization to cilium →	+0.068	+1.175	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,046 associations by consensus.

Vesicle tethering to Golgi by TTC8 expression — BONE

Explore this box plot interactively →