TTC8

Across TCGA cell cohorts, TTC8 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TTC8-associated genes across cancer lineages are SEL1L2, PDYN, and ADAMDEC1. Each is linked with TTC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC8-to-partner and partner-to-TTC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEL1L2 grouped by TTC8-low versus TTC8-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC8→partner) and Y-score (partner→TTC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SEL1L2 →	+0.027	+3.362	<.001	.007	3	1
LUNG_NSCLC_LUAD	PDYN →	+0.008	+3.215	.002	.007	3	1
LUNG_NSCLC_LUAD	ADAMDEC1 →	+0.012	+3.604	.002	.004	3	1
LUNG_NSCLC_LUAD	GABRA6 →	+0.051	+3.604	<.001	.004	3	1
LUNG_NSCLC_LUAD	SAMD3 →	+1.009	+3.484	<.001	.009	3	1
LUNG_NSCLC_LUAD	SSMEM1 →	+0.058	+3.906	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

SEL1L2 by TTC8 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →