TTC8

Across TCGA cell cohorts, TTC8 mutation is significantly associated with the mutation status of many other genes, with 659 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTC8-associated genes across cancer lineages are ITPR1, RHOA, and IPO4. Each is linked with TTC8 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTC8-to-partner and partner-to-TTC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITPR1 grouped by TTC8-low versus TTC8-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC8→partner) and Y-score (partner→TTC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ITPR1 →	+3.608	+3.906	.004	.004	1	3
UPPER_AERODIGESTIVE_TRACT	RHOA →	+4.193	+4.193	.002	.002	1	3
UPPER_AERODIGESTIVE_TRACT	IPO4 →	+3.608	+3.906	.004	.004	1	3
BLOOD_Leukemia	GTF3C4 →	+4.321	+5.285	.005	.005	1	2
BLOOD_Leukemia	PLD2 →	+4.000	+5.050	.008	.008	1	2
BLOOD_Leukemia	FOXF2 →	+6.321	+6.321	.001	.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 659 associations by consensus.

ITPR1 by TTC8 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →