TTC7B

Across TCGA patient cohorts, TTC7B mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC7B-associated genes across cancer lineages are Shc_pY317, ERK2, and MEK1. Each is linked with TTC7B in more than 2 cancer types. Because this analysis shows association rather than direction, both TTC7B-to-partner and partner-to-TTC7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by TTC7B-low versus TTC7B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC7B→partner) and Y-score (partner→TTC7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.116	-0.999	.008	.042	3	3
UCEC	ERK2 →	+0.120	+1.440	.029	.022	3	2
UCEC	MEK1 →	+0.388	+4.087	<.001	<.001	3	2
UCEC	MSH6 →	-0.314	-1.736	<.001	.005	3	2
UCEC	Claudin-7 →	+0.344	+2.807	.017	.002	3	2
SKCM	p90 RSK →	+0.253	+2.321	.016	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Shc_pY317 by TTC7B expression — UCEC

Explore this box plot interactively →