TTC7B

Across TCGA pan-cancer cohorts, TTC7B RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TTC7B data layer compared with 9 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TTC7B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TTC7B expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCEC show a favorable association.

HNSC, BLCA, and KIRC are the cancer types where TTC7B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.584	0.750	<.001	135	view →
BLCA	DFS	Quartile	II,III,IV	0.408	0.599	<.001	100	view →
KIRC	OS	Tertile	All	0.736	0.529	<.001	48	view →
UCEC	DFS	Median	IV	0.869	0.493	.004	40	view →
ACC	DFS	Quartile	II,III,IV	0.482	0.812	.011	31	view →
LUSC	DFS	Median	III,IV	0.235	0.560	<.001	30	view →
PAAD	DFS	Median	All	0.437	0.286	.003	29	view →
MESO	OS	Median	All	0.279	0.490	.001	25	view →
BRCA	DFS	Median	III,IV	0.863	0.721	.001	25	view →
KIRP	DFS	Tertile	All	0.896	0.976	.010	22	view →
ESCA	DFS	Tertile	All	0.886	0.360	.016	18	view →
COAD	DFS	Median	All	0.722	0.850	.002	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TTC7B–HNSC (OS)

Open the HNSC breakdown →