TTC7B

Across TCGA pan-cancer cohorts, TTC7B RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TTC7B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TTC7B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TTC7B is over-expressed in tumor, although a few such as LUAD and BRCA show the opposite, repressed pattern.

HNSC, LUAD, and BRCA are the cancer types where TTC7B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTC7B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.234	<.001	11	view →
LUAD	Female	II,III,IV	−0.790	<.001	8	view →
BRCA	All	III,IV	−0.613	<.001	6	view →
KICH	All	II,III,IV	+0.556	<.001	5	view →
THCA	Male	II,III,IV	−0.493	.002	3	view →
KIRC	Male	II,III,IV	−0.341	.003	3	view →
KIRP	All	II,III,IV	+0.406	.028	2	view →
UCEC	All	All	−0.394	.010	2	view →
READ	Female	All	−1.122	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TTC7B–HNSC

Open the HNSC breakdown →