TTC7B

Across TCGA cell cohorts, TTC7B mutation is significantly associated with the RNA expression of many other genes, with 251 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTC7B-associated genes across cancer lineages are MDH1B, TUBA3E, and MTHFD2L. Each is linked with TTC7B in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC7B-to-partner and partner-to-TTC7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MDH1B grouped by TTC7B-low versus TTC7B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC7B→partner) and Y-score (partner→TTC7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MDH1B →	+0.590	+3.234	<.001	.004	3	2
LARGE_INTESTINE	TUBA3E →	+0.094	+2.591	.001	.007	3	2
LARGE_INTESTINE	MTHFD2L →	+0.667	+3.212	.002	.006	3	2
LARGE_INTESTINE	DNAH10 →	+0.756	+3.212	<.001	.006	3	2
LUNG_NSCLC_LUAD	OR52W1 →	+0.036	+2.584	.001	.005	3	2
BLOOD_Leukemia	VWC2L →	+0.011	+3.076	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 251 associations by consensus.

MDH1B by TTC7B expression — LARGE_INTESTINE

Explore this box plot interactively →