TTC7A

Across TCGA cell cohorts, TTC7A mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTC7A-associated genes across cancer lineages are CWH43, GFRA1, and KCNIP1. Each is linked with TTC7A in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC7A-to-partner and partner-to-TTC7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CWH43 grouped by TTC7A-low versus TTC7A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC7A→partner) and Y-score (partner→TTC7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CWH43 →	+1.103	+3.491	<.001	.004	3	1
LARGE_INTESTINE	GFRA1 →	+0.104	+3.333	.001	.009	3	1
LARGE_INTESTINE	KCNIP1 →	+0.039	+3.472	.009	.005	3	1
LARGE_INTESTINE	SPESP1 →	+0.643	+3.906	.002	.001	3	1
LARGE_INTESTINE	MYO3A →	+0.607	+3.491	<.001	.008	3	1
BLOOD_Leukemia	CALHM4 →	+0.020	+3.269	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

CWH43 by TTC7A expression — LARGE_INTESTINE

Explore this box plot interactively →