TTC7A

Across TCGA pan-cancer cohorts, TTC7A RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TTC7A data layer compared with 2 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TTC7A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TTC7A expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

KIRC, LGG, and SKCM are the cancer types where TTC7A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	All	0.784	0.434	<.001	65	view →
LGG	DFS	Median	All	0.272	0.497	<.001	54	view →
SKCM	OS	Quartile	All	0.479	0.299	<.001	44	view →
OV	OS	Tertile	All	0.281	0.418	<.001	44	view →
ACC	DFS	Tertile	All	0.267	0.688	.005	42	view →
LIHC	OS	Quartile	All	0.631	0.839	.001	42	view →
CHOL	DFS	Median	III,IV	0.647	0.127	.006	27	view →
SCLC	DFS	Quartile	All	0.762	0.374	<.001	25	view →
PAAD	DFS	Quartile	All	0.188	0.505	.002	24	view →
COAD	DFS	Median	All	0.715	0.838	.005	24	view →
THYM	OS	Median	All	1.000	0.715	<.001	16	view →
KIRP	DFS	Median	IV	0.039	0.526	.027	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TTC7A–KIRC (DFS)

Open the KIRC breakdown →