TTC39A-AS1

Across TCGA pan-cancer cohorts, TTC39A-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TTC39A-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TTC39A-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types TTC39A-AS1 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and LUSC are the cancer types where TTC39A-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTC39A-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	II,III,IV	−0.628	<.001	12	view →
LUAD	All	II,III,IV	−0.605	<.001	9	view →
LUSC	Female	All	−1.275	<.001	8	view →
KIRP	Male	All	+0.282	<.001	8	view →
LIHC	All	All	+0.360	<.001	7	view →
BRCA	All	All	+0.496	.001	4	view →
CHOL	Female	All	+1.890	<.001	3	view →
STAD	Male	IV	−0.960	.001	2	view →
PRAD	All	All	+0.668	<.001	2	view →
KICH	All	All	+0.403	.007	2	view →
THCA	All	IV	−0.607	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TTC39A-AS1–HNSC

Open the HNSC breakdown →