TTC21B

Across TCGA patient cohorts, TTC21B mutation is significantly associated with the RNA expression of many other genes, with 3,816 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC21B-associated genes across cancer lineages are FCER1A, PDHX, and PPP2CA. Each is linked with TTC21B in more than 3 cancer types. Because this analysis shows association rather than direction, both TTC21B-to-partner and partner-to-TTC21B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCER1A grouped by TTC21B-low versus TTC21B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC21B→partner) and Y-score (partner→TTC21B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FCER1A →	-0.798	-2.321	<.001	<.001	3	4
UCEC	PDHX →	+0.425	+1.938	<.001	<.001	3	4
UCEC	PPP2CA →	+0.267	+2.606	.002	<.001	3	4
UCEC	ECHS1 →	+0.300	+2.108	.004	<.001	3	4
HNSC	RNU6-260P →	+0.530	+4.063	<.001	.004	3	3
UCEC	TMEM163 →	-0.349	-1.667	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,816 associations by consensus.

FCER1A by TTC21B expression — UCEC

Explore this box plot interactively →