TTC21B

Across TCGA pan-cancer cohorts, TTC21B RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of TTC21B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TTC21B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TTC21B is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, KICH, and THCA are the cancer types where TTC21B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTC21B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.659	<.001	9	view →
KICH	Female	All	−1.431	<.001	8	view →
THCA	All	II,III,IV	−0.592	<.001	8	view →
LIHC	Female	II,III,IV	+0.832	<.001	7	view →
CHOL	All	All	+1.254	<.001	5	view →
HNSC	All	II,III,IV	+0.312	.014	5	view →
BRCA	Female	All	−0.287	<.001	4	view →
KIRP	Female	II,III,IV	+0.640	.037	2	view →
UCEC	All	All	−0.506	.026	2	view →
LUAD	Female	II,III,IV	−0.490	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

TTC21B–KIRC

Open the KIRC breakdown →