TTC21B

Across TCGA pan-cancer cohorts, TTC21B RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TTC21B data layer compared with 8 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TTC21B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TTC21B expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

ACC, KIRC, and KIRP are the cancer types where TTC21B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.330	0.818	<.001	118	view →
KIRC	DFS	Quartile	All	0.738	0.434	<.001	65	view →
KIRP	DFS	Quartile	All	0.507	0.774	<.001	56	view →
LIHC	DFS	Tertile	All	0.467	0.634	.001	42	view →
UCS	DFS	Median	IV	0.952	0.367	.001	36	view →
HNSC	OS	Median	All	0.240	0.571	<.001	35	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
BRCA	DFS	Tertile	III,IV	0.566	0.349	.002	22	view →
LGG	OS	Median	All	0.740	0.912	<.001	20	view →
THYM	DFS	Tertile	All	1.000	0.614	.007	16	view →
UCEC	DFS	Median	II,III,IV	0.666	0.797	.011	16	view →
OV	OS	Quartile	III,IV	0.262	0.366	.022	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TTC21B–ACC (DFS)

Open the ACC breakdown →