TTC21B

Across TCGA patient cohorts, TTC21B mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC21B-associated genes across cancer lineages are Rab25, eEF2, and ASNS. Each is linked with TTC21B in more than 3 cancer types. Because this analysis shows association rather than direction, both TTC21B-to-partner and partner-to-TTC21B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by TTC21B-low versus TTC21B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC21B→partner) and Y-score (partner→TTC21B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.356	-3.807	<.001	<.001	3	4
STAD	eEF2 →	+0.333	+3.000	.033	.036	3	3
COAD	ASNS →	+0.545	+2.330	.002	.020	3	3
UCEC	INPP4B →	-0.230	-2.222	.020	.009	3	3
UCEC	ATM →	-0.407	-1.473	.003	.006	3	3
UCEC	4E-BP1 →	+0.273	+1.795	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Rab25 by TTC21B expression — UCEC

Explore this box plot interactively →