TTC21B

Across TCGA cell cohorts, TTC21B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,710 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TTC21B-associated GO terms across cancer lineages are Centriole replication, Subtelomeric heterochromatin formation, and Regulation of microtubule-based process. Each is linked with TTC21B in more than 17 cancer types. Because this analysis shows association rather than direction, both TTC21B-to-partner and partner-to-TTC21B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Centriole replication grouped by TTC21B-low versus TTC21B-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC21B→partner) and Y-score (partner→TTC21B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Centriole replication →	+0.113	+1.039	<.001	<.001	3	18
PANCREAS	Subtelomeric heterochromatin formation →	+0.105	+0.563	<.001	.002	3	17
LUNG_NSCLC_LUSC	Regulation of microtubule-based process →	+0.071	+1.231	<.001	.009	3	17
SOFT_TISSUE	Regulation of chromosome organization →	+0.087	+0.990	<.001	<.001	3	17
SOFT_TISSUE	Centrosome duplication →	+0.095	+0.983	<.001	<.001	3	17
SOFT_TISSUE	Mitotic sister chromatid segregation →	+0.107	+0.768	<.001	.005	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,710 associations by consensus.

Centriole replication by TTC21B expression — SOFT_TISSUE

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