TTC21B

Across TCGA cell cohorts, TTC21B mutation is significantly associated with the RNA expression of many other genes, with 556 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTC21B-associated genes across cancer lineages are SYNPR, HTR1B, and RAB3C. Each is linked with TTC21B in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC21B-to-partner and partner-to-TTC21B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYNPR grouped by TTC21B-low versus TTC21B-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC21B→partner) and Y-score (partner→TTC21B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SYNPR →	+0.500	+3.736	<.001	.008	3	2
UPPER_AERODIGESTIVE_TRACT	HTR1B →	+0.130	+3.362	.003	.003	3	2
UPPER_AERODIGESTIVE_TRACT	RAB3C →	+0.051	+3.528	.003	.006	3	2
UPPER_AERODIGESTIVE_TRACT	VWC2L →	+0.011	+3.624	.001	.001	3	2
UPPER_AERODIGESTIVE_TRACT	TMEM132E →	+0.032	+4.491	<.001	.002	3	2
UPPER_AERODIGESTIVE_TRACT	SLC22A10 →	+0.393	+3.362	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 556 associations by consensus.

SYNPR by TTC21B expression — SOFT_TISSUE

Explore this box plot interactively →