TTC21A

Across TCGA patient cohorts, TTC21A mutation is significantly associated with the RNA expression of many other genes, with 6,013 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC21A-associated genes across cancer lineages are PSMA3, RAB33A, and EMID1. Each is linked with TTC21A in more than 2 cancer types. Because this analysis shows association rather than direction, both TTC21A-to-partner and partner-to-TTC21A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMA3 grouped by TTC21A-low versus TTC21A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC21A→partner) and Y-score (partner→TTC21A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMA3 →	+0.344	+3.152	<.001	<.001	3	3
UCEC	RAB33A →	+0.325	+1.960	.009	.008	3	3
UCEC	EMID1 →	-1.162	-1.574	<.001	<.001	3	3
SKCM	TSPY26P →	-0.756	-2.364	.001	.003	3	3
HNSC	RNA5SP88 →	+0.317	+5.468	<.001	.002	3	2
UCEC	PHF5A →	+0.526	+2.662	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,013 associations by consensus.

PSMA3 by TTC21A expression — UCEC

Explore this box plot interactively →