TTC21A

Across TCGA cell cohorts, TTC21A mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTC21A-associated genes across cancer lineages are SPATA31E1, STH, and TMEM35A. Each is linked with TTC21A in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC21A-to-partner and partner-to-TTC21A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA31E1 grouped by TTC21A-low versus TTC21A-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC21A→partner) and Y-score (partner→TTC21A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SPATA31E1 →	+0.166	+4.906	<.001	.006	3	1
OESOPHAGUS	STH →	+0.076	+4.906	<.001	.006	3	1
URINARY_TRACT	TMEM35A →	+0.684	+3.611	.006	.003	3	1
URINARY_TRACT	TGIF2LX →	+1.191	+3.906	<.001	.001	3	1
URINARY_TRACT	HLA-DQB2 →	+0.080	+4.108	<.001	.005	3	1
URINARY_TRACT	SMIM34A →	+0.181	+3.700	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

SPATA31E1 by TTC21A expression — OESOPHAGUS

Explore this box plot interactively →