TTBK2

Across TCGA patient cohorts, TTBK2 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTBK2-associated genes across cancer lineages are CD20, eIF4G, and Cyclin-E2. Each is linked with TTBK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTBK2-to-partner and partner-to-TTBK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD20 grouped by TTBK2-low versus TTBK2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTBK2→partner) and Y-score (partner→TTBK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	CD20 →	+0.095	+2.195	.032	.032	3	3
UCEC	eIF4G →	+0.258	+2.222	.005	.009	3	3
BLCA	Cyclin-E2 →	+0.218	+2.321	.008	.035	3	2
UCEC	EGFR_pY1068 →	-0.174	-1.678	.019	.019	3	2
UCEC	eIF4E →	+0.178	+2.247	.004	.001	3	2
UCEC	FASN →	+0.295	+1.378	.012	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

CD20 by TTBK2 expression — BLCA

Explore this box plot interactively →