TTBK2

Across TCGA pan-cancer cohorts, TTBK2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TTBK2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TTBK2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TTBK2 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, THCA, and UCEC are the cancer types where TTBK2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTBK2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.877	<.001	12	view →
THCA	Male	II,III,IV	−0.771	<.001	10	view →
UCEC	All	All	−1.097	<.001	6	view →
BRCA	Female	All	−0.553	<.001	6	view →
LUAD	All	All	−0.360	.001	6	view →
CHOL	All	All	+1.058	<.001	5	view →
LIHC	All	All	+0.294	<.001	5	view →
COAD	All	All	−0.294	.005	4	view →
BLCA	All	IV	−0.717	.047	1	view →
READ	All	All	−0.530	.043	1	view →
KIRP	Female	All	+0.436	.015	1	view →
KIRC	All	All	+0.178	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TTBK2–HNSC

Open the HNSC breakdown →