TTBK2

Across TCGA pan-cancer cohorts, TTBK2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TTBK2 data layer compared with 8 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher TTBK2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TTBK2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

KICH, UVM, and SKCM are the cancer types where TTBK2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	All	0.677	1.000	.002	63	view →
UVM	DFS	Tertile	III,IV	0.241	0.871	<.001	58	view →
SKCM	OS	Tertile	All	0.404	0.249	<.001	49	view →
ACC	DFS	Quartile	All	0.235	0.746	<.001	28	view →
KIRC	DFS	Quartile	All	0.920	0.748	.004	27	view →
HNSC	OS	Median	All	0.612	0.798	.001	27	view →
OV	OS	Tertile	All	0.786	0.880	.022	20	view →
ESCA	DFS	Median	All	0.918	0.495	.012	18	view →
SARC	DFS	Tertile	All	0.672	0.488	.003	18	view →
BRCA	DFS	Quartile	III,IV	0.932	0.750	.003	17	view →
LUSC	DFS	Tertile	III,IV	0.243	0.567	.004	16	view →
SCLC	OS	Quartile	II,III,IV	0.847	0.457	.002	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TTBK2–KICH (OS)

Open the KICH breakdown →