TTBK2

Across TCGA cell cohorts, TTBK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,677 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TTBK2-associated GO terms across cancer lineages are Microtubule polymerization, Microtubule nucleation, and Regulation of organelle assembly. Each is linked with TTBK2 in more than 17 cancer types. Because this analysis shows association rather than direction, both TTBK2-to-partner and partner-to-TTBK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule polymerization grouped by TTBK2-low versus TTBK2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TTBK2→partner) and Y-score (partner→TTBK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Microtubule polymerization →	+0.113	+1.082	<.001	<.001	3	18
BONE	Microtubule nucleation →	+0.141	+0.824	<.001	<.001	3	18
OESOPHAGUS	Regulation of organelle assembly →	+0.050	+1.101	<.001	<.001	3	17
LUNG_SCLC	Protein polymerization →	+0.065	+0.478	.007	.009	3	17
OESOPHAGUS	Regulation of translational initiation →	+0.091	+1.221	.005	.005	3	17
UPPER_AERODIGESTIVE_TRACT	Viral translational termination-reinitiation →	+0.106	+0.858	<.001	.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,677 associations by consensus.

Microtubule polymerization by TTBK2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →