TTBK2

Across TCGA cell cohorts, TTBK2 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TTBK2-associated genes across cancer lineages are DKK4, SPINK9, and DCSTAMP. Each is linked with TTBK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTBK2-to-partner and partner-to-TTBK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DKK4 grouped by TTBK2-low versus TTBK2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTBK2→partner) and Y-score (partner→TTBK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DKK4 →	+0.132	+3.836	.002	.004	3	2
BLOOD_Myeloma	SPINK9 →	+0.051	+3.285	.003	.009	3	1
PANCREAS	DCSTAMP →	+0.018	+5.000	.001	.006	3	1
PANCREAS	MYH6 →	+0.006	+5.000	<.001	.006	3	1
PANCREAS	LINC02881 →	+0.022	+5.000	<.001	.006	3	1
URINARY_TRACT	DCLK3 →	+0.056	+3.523	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

DKK4 by TTBK2 expression — URINARY_TRACT

Explore this box plot interactively →