TTBK1

Across TCGA patient cohorts, TTBK1 mutation is significantly associated with the RNA expression of many other genes, with 5,506 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTBK1-associated genes across cancer lineages are OR2T1, CRYBB2P1, and PGK1. Each is linked with TTBK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TTBK1-to-partner and partner-to-TTBK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T1 grouped by TTBK1-low versus TTBK1-high in SARC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTBK1→partner) and Y-score (partner→TTBK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	OR2T1 →	+0.038	+4.954	.003	.004	3	3
UCEC	CRYBB2P1 →	+0.397	+2.566	.002	<.001	3	3
UCEC	PGK1 →	+0.762	+2.754	<.001	<.001	3	3
COAD	ARHGEF10 →	+0.683	+3.459	<.001	.005	3	3
UCEC	BNIP3L →	+0.651	+2.378	<.001	<.001	3	3
UCEC	TLE6 →	+0.540	+1.545	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,506 associations by consensus.

OR2T1 by TTBK1 expression — SARC

Explore this box plot interactively →