TTBK1

Across TCGA pan-cancer cohorts, TTBK1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TTBK1 data layer compared with 11 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TTBK1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TTBK1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LIHC show a favorable association.

HNSC, UVM, and LIHC are the cancer types where TTBK1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.752	0.578	<.001	109	view →
UVM	DFS	Tertile	II,III,IV	0.393	0.744	<.001	87	view →
LIHC	OS	Median	III,IV	0.691	0.344	<.001	71	view →
BLCA	OS	Quartile	III,IV	0.748	0.330	<.001	65	view →
MESO	OS	Median	All	0.293	0.468	.004	56	view →
DLBC	DFS	Tertile	III,IV	0.222	0.862	.002	44	view →
READ	OS	Median	All	1.000	0.812	.004	42	view →
UCEC	OS	Tertile	All	0.884	0.952	.001	36	view →
SCLC	DFS	Median	II,III,IV	0.819	0.205	.004	21	view →
CESC	OS	Tertile	IV	0.730	0.112	.017	18	view →
ESCA	OS	Median	All	0.617	1.000	.009	18	view →
SKCM	OS	Quartile	All	0.485	0.326	.006	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TTBK1–HNSC (DFS)

Open the HNSC breakdown →