TTBK1

Across TCGA pan-cancer cohorts, TTBK1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TTBK1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TTBK1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TTBK1 is over-expressed in tumor, although a few such as KICH and CHOL show the opposite, repressed pattern.

HNSC, KICH, and KIRC are the cancer types where TTBK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTBK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.156	<.001	11	view →
KICH	All	II,III,IV	−0.562	<.001	9	view →
KIRC	All	All	+0.343	<.001	8	view →
BRCA	All	II,III,IV	+0.219	<.001	8	view →
LUAD	All	All	+0.202	<.001	8	view →
LUSC	All	All	+0.328	<.001	6	view →
THCA	Female	All	+0.133	<.001	6	view →
CHOL	All	All	−0.839	<.001	4	view →
UCEC	All	All	+0.183	.045	4	view →
PAAD	Male	All	+0.655	.027	2	view →
PRAD	All	All	−0.250	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TTBK1–HNSC

Open the HNSC breakdown →