TTBK1

Across TCGA patient cohorts, TTBK1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTBK1-associated genes across cancer lineages are GATA3, p90 RSK, and Cyclin-D1. Each is linked with TTBK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTBK1-to-partner and partner-to-TTBK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA3 grouped by TTBK1-low versus TTBK1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTBK1→partner) and Y-score (partner→TTBK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GATA3 →	+0.181	+3.593	.041	.001	3	3
SKCM	p90 RSK →	+0.206	+2.000	.006	.008	3	3
LUAD	Cyclin-D1 →	-0.195	-3.000	.030	.036	3	2
CESC	p70-S6K_pT389 →	+0.179	+2.842	.015	.032	3	2
UCEC	p62 Lck ligand →	+0.424	+3.392	<.001	<.001	3	2
UCEC	ATM →	-0.614	-2.247	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

GATA3 by TTBK1 expression — COAD

Explore this box plot interactively →