TTBK1

Across TCGA cell cohorts, TTBK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,346 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible TTBK1-associated GO terms across cancer lineages are Negative regulation of calcium ion export across plasma membrane, Regulation of myoblast fusion, and Mitochondrial electron transport, cytochrome c to oxygen. Each is linked with TTBK1 in more than 7 cancer types. Because this analysis shows association rather than direction, both TTBK1-to-partner and partner-to-TTBK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion export across plasma membrane grouped by TTBK1-low versus TTBK1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TTBK1→partner) and Y-score (partner→TTBK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.054	+0.022	.001	.003	3	8
LUNG_SCLC	Regulation of myoblast fusion →	+0.101	+1.719	<.001	.003	3	7
OVARY	Mitochondrial electron transport, cytochrome c to oxygen →	+0.093	+0.142	<.001	.001	3	7
BREAST	Organelle membrane fusion →	+0.044	+0.152	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	Purine nucleoside triphosphate biosynthetic process →	+0.073	+0.020	<.001	.007	3	6
UPPER_AERODIGESTIVE_TRACT	Purine ribonucleoside triphosphate biosynthetic process →	+0.073	+0.020	<.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,346 associations by consensus.

Negative regulation of calcium ion export across plasma membrane by TTBK1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →