TTBK1

Across TCGA cell cohorts, TTBK1 mutation is significantly associated with the RNA expression of many other genes, with 1,082 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTBK1-associated genes across cancer lineages are PATE1, BMF, and MTMR4. Each is linked with TTBK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTBK1-to-partner and partner-to-TTBK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PATE1 grouped by TTBK1-low versus TTBK1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTBK1→partner) and Y-score (partner→TTBK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PATE1 →	+0.016	+4.169	.003	.002	3	2
LARGE_INTESTINE	BMF →	-0.932	-2.657	.003	.002	3	2
LARGE_INTESTINE	MTMR4 →	+0.549	+2.043	.009	.008	3	2
LARGE_INTESTINE	PIGL →	+0.621	+3.321	.005	.003	3	2
LARGE_INTESTINE	TBCCD1 →	+0.478	+2.043	.007	.008	3	2
LARGE_INTESTINE	ALDH6A1 →	+0.775	+3.234	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,082 associations by consensus.

PATE1 by TTBK1 expression — SOFT_TISSUE

Explore this box plot interactively →