TST

Across TCGA patient cohorts, TST mutation is significantly associated with the RNA expression of many other genes, with 322 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TST-associated genes across cancer lineages are RNU6-1313P, SNORD116-10, and DEFB136. Each is linked with TST in more than 1 cancer types. Because this analysis shows association rather than direction, both TST-to-partner and partner-to-TST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1313P grouped by TST-low versus TST-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TST→partner) and Y-score (partner→TST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-1313P →	+0.461	+5.343	<.001	.006	3	2
SKCM	SNORD116-10 →	+0.188	+4.039	<.001	.009	3	2
SKCM	DEFB136 →	+0.315	+4.120	.002	<.001	3	2
SKCM	OR5K1 →	+0.017	+4.212	<.001	.007	3	2
LUAD	RNU6-275P →	+0.495	+5.157	<.001	.007	3	2
LUAD	GAPDHP53 →	+0.070	+6.912	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 322 associations by consensus.

RNU6-1313P by TST expression — LUAD

Explore this box plot interactively →