TST

Across TCGA pan-cancer cohorts, TST RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TST’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TST RNA is repressed in tumor relative to normal tissue. In most cancer types TST is over-expressed in tumor, although a few such as COAD and KIRP show the opposite, repressed pattern.

COAD, KIRP, and KICH are the cancer types where TST tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TST RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−1.384	<.001	11	view →
KIRP	All	All	−0.709	<.001	11	view →
KICH	All	III,IV	−1.527	<.001	10	view →
HNSC	All	II,III,IV	−0.620	<.001	9	view →
KIRC	Male	All	−1.004	<.001	7	view →
BRCA	All	II,III,IV	−0.516	<.001	6	view →
THCA	All	All	+0.327	<.001	4	view →
READ	All	All	−0.978	.008	2	view →
CHOL	All	All	−0.881	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TST–COAD

Open the COAD breakdown →