TSSK6

Across TCGA patient cohorts, TSSK6 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSSK6-associated genes across cancer lineages are MEK1, GAPDH, and JNK2. Each is linked with TSSK6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSSK6-to-partner and partner-to-TSSK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by TSSK6-low versus TSSK6-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSSK6→partner) and Y-score (partner→TSSK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MEK1 →	+0.253	+3.021	.009	.018	3	2
UCEC	GAPDH →	+0.540	+2.459	.021	.019	3	2
UCEC	JNK2 →	+0.354	+3.026	<.001	.018	3	2
UCEC	ATM →	-0.583	-3.156	.003	.018	3	2
UCEC	eEF2K →	+0.300	+1.598	.048	.044	3	2
STAD	Src_pY527 →	-0.654	-3.000	.010	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

MEK1 by TSSK6 expression — STAD

Explore this box plot interactively →