TSPO

Across TCGA patient cohorts, TSPO RNA expression is significantly associated with the protein abundance of many other proteins, with 13,958 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TSPO-associated proteins across cancer lineages are SMC1A, ANXA1, and CDCP1. Each is linked with TSPO in more than 6 cancer types. Because this analysis shows association rather than direction, both TSPO-to-partner and partner-to-TSPO results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TSPO versus SMC1A in GBM, with a Pearson correlation of -0.51.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPO→partner) and Y-score (partner→TSPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC1A →	-0.291	-0.570	<.001	.001	3	5
UCEC	ANXA1 →	+0.707	+1.449	<.001	.002	1	7
CCRCC	CDCP1 →	+0.773	+0.340	<.001	<.001	3	5
LSCC	GIPC1 →	+0.372	+0.663	<.001	<.001	3	5
CCRCC	GMIP →	+0.327	+0.344	<.001	<.001	3	5
BRCA	MEF2D_S444 →	-0.587	-1.176	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,958 associations by consensus.

TSPO vs SMC1A — GBM

Explore this scatter interactively →