TSPO

Across TCGA pan-cancer cohorts, TSPO RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TSPO data layer compared with 1 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher TSPO RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TSPO expression acts as an unfavorable survival marker, although some lineages such as ESCA and HNSC show a favorable association.

OV, LGG, and KIRC are the cancer types where TSPO RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	III,IV	0.119	0.193	.006	54	view →
LGG	DFS	Median	All	0.665	0.810	<.001	47	view →
KIRC	DFS	Quartile	All	0.810	0.912	<.001	38	view →
ESCA	OS	Quartile	All	0.817	0.547	.004	31	view →
ACC	DFS	Tertile	All	0.221	0.685	.003	29	view →
LIHC	OS	Tertile	All	0.396	0.630	.001	29	view →
HNSC	OS	Tertile	All	0.822	0.718	.003	27	view →
UCS	OS	Median	IV	0.292	0.738	.011	24	view →
PAAD	DFS	Quartile	All	0.147	0.457	<.001	24	view →
KIRP	DFS	Median	IV	0.039	0.526	.027	16	view →
SKCM	OS	Tertile	All	0.252	0.397	.002	15	view →
LAML	DFS	Median	All	0.287	0.453	.013	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TSPO–OV (DFS)

Open the OV breakdown →